For a healthy adult, the **absolute maximum acetaminophen dose is 4,000 mg (4 g) in 24 hours**, from all products combined. Many clinicians recommend staying at or below **3,000 mg/day**, especially for repeated use.
- Typical dose: **650–1,000 mg every 4–6 hours**
- Do not combine multiple acetaminophen-containing products (sometimes labeled **APAP**)
- Use a lower limit or ask a clinician if you have liver disease, drink 3+ alcoholic drinks daily, are underweight/malnourished, or take it for several days
An overdose can cause severe liver damage; contact Poison Control promptly if the limit may have been exceeded (U.S.: **1-800-222-1222**).