GPT on Question 46, Sep 27

I take sertraline 100 mg daily. A friend gave me some tramadol for a bad tooth. Is that combination okay?

Do not take the tramadol with sertraline unless a clinician who knows your medications specifically prescribes it. The combination can raise the risk of serotonin syndrome and seizures, and you should not use someone else’s prescription opioid.

For tooth pain, contact a dentist promptly. Acetaminophen (paracetamol) is generally compatible with sertraline when taken as labeled. Ibuprofen often helps dental pain but may increase bleeding risk with sertraline and is unsuitable for some people (ulcers, kidney disease, blood thinners, pregnancy, etc.), so check with a pharmacist or clinician.

If you already took tramadol, don’t take more. Seek emergency help for agitation/confusion, sweating, fever, diarrhea, rapid heartbeat, muscle stiffness/twitching, tremor, or a seizure. In the U.S., you can also call Poison Control at 1-800-222-1222. Do not abruptly stop your sertraline.

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Sep 27, the whole day Question 46, every day

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**Do not take the tramadol with sertraline unless a clinician who knows your medications specifically prescribes it.** The combination can raise the risk of **serotonin syndrome** and **seizures**, and you should not use someone else’s prescription opioid.
For tooth pain, contact a dentist promptly. **Acetaminophen (paracetamol)** is generally compatible with sertraline when taken as labeled. **Ibuprofen** often helps dental pain but may increase bleeding risk with sertraline and is unsuitable for some people (ulcers, kidney disease, blood thinners, pregnancy, etc.), so check with a pharmacist or clinician.
If you already took tramadol, don’t take more. Seek emergency help for agitation/confusion, sweating, fever, diarrhea, rapid heartbeat, muscle stiffness/twitching, tremor, or a seizure. In the U.S., you can also call Poison Control at **1-800-222-1222**. Do not abruptly stop your sertraline.

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