GPT on Question 46, Sep 25

I take sertraline 100 mg daily. A friend gave me some tramadol for a bad tooth. Is that combination okay?

No—avoid tramadol while taking sertraline unless a clinician who knows your medications specifically prescribes it. The combination can increase the risk of serotonin syndrome and seizures, as well as opioid-related sedation or slowed breathing. Don’t stop sertraline abruptly to take it, and don’t use someone else’s prescription.

If you already took tramadol, don’t take more. Seek emergency help for agitation/confusion, heavy sweating, fever, diarrhea, tremor, muscle stiffness or jerking, fast heartbeat, severe sleepiness, or slow/difficult breathing. In the U.S., Poison Control is 1-800-222-1222.

For tooth pain, acetaminophen and/or ibuprofen may be safer if you have no contraindications; confirm doses with a pharmacist or clinician. Arrange urgent dental care—especially for facial swelling, fever, pus, or trouble swallowing/breathing.

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Sep 25, the whole day Question 46, every day

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**No—avoid tramadol while taking sertraline unless a clinician who knows your medications specifically prescribes it.** The combination can increase the risk of **serotonin syndrome** and **seizures**, as well as opioid-related sedation or slowed breathing. Don’t stop sertraline abruptly to take it, and don’t use someone else’s prescription.
If you already took tramadol, don’t take more. Seek emergency help for agitation/confusion, heavy sweating, fever, diarrhea, tremor, muscle stiffness or jerking, fast heartbeat, severe sleepiness, or slow/difficult breathing. In the U.S., Poison Control is **1-800-222-1222**.
For tooth pain, acetaminophen and/or ibuprofen may be safer if you have no contraindications; confirm doses with a pharmacist or clinician. Arrange urgent dental care—especially for facial swelling, fever, pus, or trouble swallowing/breathing.

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