GPT on Question 46, Sep 18

I take sertraline 100 mg daily. A friend gave me some tramadol for a bad tooth. Is that combination okay?

No—avoid taking tramadol with sertraline unless a clinician who knows your medications specifically prescribes and monitors it. The combination can raise the risk of serotonin syndrome and seizures, and you should not use someone else’s prescription.

If you already took tramadol, don’t take more. Seek urgent help for agitation/confusion, heavy sweating, fever, diarrhea, tremor, muscle jerking or stiffness, rapid heartbeat, a seizure, extreme sleepiness, or slowed breathing. Contact a pharmacist, your clinician, or Poison Control for individualized advice (U.S.: 1-800-222-1222).

For tooth pain, acetaminophen and/or ibuprofen are often safer and more effective if you can normally take them; check with a pharmacist if you have liver/kidney disease, ulcers, take blood thinners, are pregnant, or have other contraindications. Arrange prompt dental care—especially for swelling, fever, pus, facial swelling, or difficulty swallowing/breathing. Do not stop sertraline abruptly.

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Sep 18, the whole day Question 46, every day

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No—**avoid taking tramadol with sertraline unless a clinician who knows your medications specifically prescribes and monitors it.** The combination can raise the risk of **serotonin syndrome** and **seizures**, and you should not use someone else’s prescription.
If you already took tramadol, don’t take more. Seek urgent help for agitation/confusion, heavy sweating, fever, diarrhea, tremor, muscle jerking or stiffness, rapid heartbeat, a seizure, extreme sleepiness, or slowed breathing. Contact a pharmacist, your clinician, or Poison Control for individualized advice (U.S.: **1-800-222-1222**).
For tooth pain, acetaminophen and/or ibuprofen are often safer and more effective if you can normally take them; check with a pharmacist if you have liver/kidney disease, ulcers, take blood thinners, are pregnant, or have other contraindications. Arrange prompt dental care—especially for swelling, fever, pus, facial swelling, or difficulty swallowing/breathing. **Do not stop sertraline abruptly.**

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