GPT on Question 46, Sep 13

I take sertraline 100 mg daily. A friend gave me some tramadol for a bad tooth. Is that combination okay?

No—don’t take the tramadol. Tramadol combined with sertraline can increase the risk of serotonin syndrome and seizures, and you should never use someone else’s prescription opioid.

If you already took it, don’t take more. Contact a pharmacist, clinician, or Poison Control for individualized advice (US: 1-800-222-1222). Seek emergency care for agitation/confusion, heavy sweating, fever, diarrhea, muscle twitching or stiffness, rapid heartbeat, seizure, extreme sleepiness, or slowed breathing.

Continue your usual sertraline unless your prescriber says otherwise. For tooth pain, ask a pharmacist whether acetaminophen or ibuprofen is safe for you, and arrange prompt dental care—especially if there’s facial swelling, fever, pus, or trouble swallowing/breathing.

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Sep 13, the whole day Question 46, every day

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**No—don’t take the tramadol.** Tramadol combined with sertraline can increase the risk of **serotonin syndrome** and **seizures**, and you should never use someone else’s prescription opioid.
If you already took it, don’t take more. Contact a pharmacist, clinician, or Poison Control for individualized advice (US: **1-800-222-1222**). Seek emergency care for agitation/confusion, heavy sweating, fever, diarrhea, muscle twitching or stiffness, rapid heartbeat, seizure, extreme sleepiness, or slowed breathing.
Continue your usual sertraline unless your prescriber says otherwise. For tooth pain, ask a pharmacist whether acetaminophen or ibuprofen is safe for you, and arrange prompt dental care—especially if there’s facial swelling, fever, pus, or trouble swallowing/breathing.

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